by Brian DeChesare Comments (11)

How to Move from the Middle Office into Life Science Venture Capital

Life Science Venture Capital Jobs
If you start out working in the back or middle office, can you ever escape?

The answer might be “yes” if you run away early, or if you target industries like sales & trading, where the front office interacts with the back and middle office.

But what if you want to move into venture capital?

Most people would say it’s impossible, and until recently, I might have agreed.

But then a reader came along and shared the story of how he moved from a middle-office role to a life science venture capital firm, and I changed my mind on life science venture capital jobs:

Q: Can you summarize your story and how you won this VC role?

A: Sure. I completed an undergraduate degree in biology/medicine/biosciences, but I had lost most of my enthusiasm for the subject by the time graduation approached.

So, I began looking for other opportunities and settled on finance after I began trading stocks (and blowing up my account twice).

Since I was far behind other candidates, I studied abroad for a year and used that time to learn math and finance and give myself a better shot at internships.

Eventually, I landed a summer internship in risk management at a large bank.

I could not leverage that experience to win a full-time, front-office role, so I accepted a return offer in the same group.

Around that time, I also started learning more about cutting-edge research in life sciences, which made me realize I might be interested in the industry after all.

Venture capital careers seemed like the natural fit since they combine finance and scientific advancements.

But I felt I had no chance of breaking in without working in investment banking or equity research at a large firm, so I attempted to move into one of those first.

That didn’t work, but I won a role at a corporate finance firm that did M&A and credit advisory, and I left my risk management role to go there.

Then, I used that experience to apply to healthcare consulting, investment banking, and equity research roles. Almost everyone told me not to bother with VC roles until I had experience in one of those first.

Finally, a headhunter who specialized in healthcare equity research called me to present a VC role that had come across his desk.

I had been in touch with this headhunter for months and seen dozens of opportunities from him, but this was the first VC role he had received.

I met the firm, spoke with the Partners there, went through interviews, and won and accepted an offer.

Life science venture capital jobs: an alternative approach

Q: Thanks for sharing that, but your story seems quite unusual.

What path do most candidates follow to get into the industry?

A: The path differs depending on the type of VC fund.

Early-stage life science VC funds favor academic prowess since they spend most of their time evaluating new research and technology. Often, they recruit Ph.D.’s who have specialized in an area of interest for their firm.

An undergraduate or Master’s degree wouldn’t be seen as sufficient unless you have other, highly relevant experience (e.g., you co-founded a biotech startup).

Later-stage funds care more about finance experience and industry knowledge, so you could use roles such as healthcare investment banking or equity research to get in.

However, some academic background is helpful because you’ll still spend time evaluating new technologies and conducting due diligence. If you don’t understand the science, it’s tough to do that.

If you’re in that position, you’re better off applying to healthcare private equity roles since finance experience is far more important there.

Q: OK. You mentioned that experience related to finance, science, and entrepreneurship can improve your odds of getting in.

Can you quantify that or give specific examples?

A: You can think of it as a 30-point system, with 10 points available in each area:

  • Finance – Working in healthcare M&A or biotech equity research at a top bulge bracket bank would be 10 / 10 points. Working in finance but in an unrelated industry group would be 5 / 10, and something outside of finance would be 0 / 10.
  • Science – Earning a Ph.D. in a high-profile research area at a top 10 global university would be 10 / 10 points. An undergraduate degree, Master’s degree, or relevant research project would be 5 / 10, and no science background at all would be 0 / 10.
  • Entrepreneurship – Founding and successfully exiting a biotech startup would be 10 / 10 points. Experience with starting a company or fundraising would be 5 / 10, and no entrepreneurship experience would be 0 / 10.

To earn 30 / 30 points on this scale, you would need to be a retired CEO or Chairman, so that’s out of the question if you’re an undergrad or recent graduate.

However, you can improve your chances by getting as high a score as possible.

If you can boost your score to 15-20 points, you’ll have a shot at winning life science VC roles.

Q: But what was your score? By my count, it seems like you only had 10 points.

Didn’t you need more to break in?

A: Yes, but I also had experience starting a healthcare device company shortly after university.

The device never made it to market, but I had completed legal due diligence, spoken with potential investors, and done some fundraising.

The experience stood out and served as a major talking point in interviews.

So, I’d say my “score” was 12 – 15 points:

  • Finance: I worked at a bulge bracket bank and eventually moved into a front-office role, but I wasn’t in the healthcare group. 5 / 10.
  • Science: I did an undergraduate science/medical degree, and I had research experience, so this was 5 / 10.
  • Entrepreneurship: My fundraising experience was probably worth 2 – 5 points, depending on how the VC firm saw it.

Q: Fair enough. What questions did you receive in these venture capital interviews?

A: Interviews were very casual, and the Partners barely asked about what I had done in my risk management and corporate finance roles.

They spent most of their time asking me about:

  1. The firm’s current portfolio companies, what I thought of them, and interesting areas within life sciences.
  2. Why I wanted to do venture capital, why I liked healthcare, and how well I fit in with the culture of the firm.
  3. My experience fundraising for the healthcare device company.

They did not give me a case study or financial modeling test.

A junior-level team member had recently left the firm, and they needed a replacement right away, so the process moved quickly – it took one month from start to finish.

I was in the right place at the right time, and I had enough industry knowledge and experience to make a good impression.

Q: Is there anything you would have done differently?

A: I would have put a lot more effort into winning a role in healthcare equity research or M&A, or even a role in corporate finance at a large pharmaceutical company.

Breaking into life science VC without that background was an uphill battle, and I was quite lucky to win this opportunity.

Q: So, what is the most realistic way of breaking in for the average professional?

A: Unless you spend years completing a Ph.D., you’re unlikely to score more than 5 points in the “Science” category.

And unless you spend years starting a biotech business, you’re unlikely to earn more than a few points in the “Entrepreneurship” category.

So, your most realistic options are:

  • Complete a degree in medicine, biology, or a related field, and gain research experience. Learn accounting and finance on the side.
  • Win a healthcare finance role at a bulge bracket or elite boutique bank. If you can’t do that, go for a corporate finance role at a pharmaceutical or healthcare company.

You should aim for at least 15 / 30 points and then target later-stage funds that value finance skills.

On the other hand, if you’re a Ph.D. student or biotech startup founder, you should amass points in the Science and Entrepreneurship categories and go for earlier-stage funds.

Q: Thanks for that summary, and for your time!

A: My pleasure.

If you’re interested in venture capital roles, you might be interested in our Venture Capital Modeling & Growth Equity Modeling course.

About the Author

Brian DeChesare is the Founder of Mergers & Inquisitions and Breaking Into Wall Street. In his spare time, he enjoys lifting weights, running, traveling, obsessively watching TV shows, and defeating Sauron.

Break Into Investment Banking

Free Exclusive Report: 57-page guide with the action plan you need to break into investment banking - how to tell your story, network, craft a winning resume, and dominate your interviews

We respect your privacy. Please refer to our full privacy policy.


Read below or Add a comment

  1. Hi Brian, just came across this article today and found it very informative as I’d like to eventually move to a PE firm working with the life sciences sector. However like the person in the article I don’t have relevant enough experience and am not sure of the best route to get me there. I feel a junior equity research role at a bank/broker is my best next step moment?

    I have a life sciences degree (Pharma Chem) and am a CFA Charterholder but my work experience is back/middle office functions in investment banks so no help for getting my onto the private side.

    1. I’m not sure that equity research is the best path for PE roles because you don’t work on transactions there. It might be a bit more helpful for VC roles since transactions are simpler and easier and you don’t need to know as much.

      If your experience is mainly in the back/middle office at large banks, maybe find a healthcare boutique bank or some other valuation-related firm that focuses on the healthcare sector and move in like that. If you have a solid equity research opportunity, sure, go ahead and explore it, but you really need transaction experience to have a good shot at most PE roles, which means “investment banking” in most cases.

      1. Liam O'Connor

        Thanks for the reply Brian. I’ve been emailing firms over the last few weeks and attending networking events with professionals working on healthcare from a PE aspect. The issue I seem to keep coming across is that most of the smaller firms are only looking for the finished article and even junior analyst roles require some transaction experience. I feel like I’m hitting a brick wall at the moment but I’m guessing this is the case for most people. Are there any other events or forums you are aware of that would be good for networking? So far I have only been using the CFA events.

        1. I think it’s going to be nearly impossible to win healthcare PE roles without transaction experience. I’m not sure of other networking opportunities for that field specifically, but maybe think about healthcare VC conferences and approach it from that angle instead. VC might be somewhat easier to get into because you need more market knowledge and less transaction experience.

  2. Thank you for this informative post.
    I just have a question – I am graduating with a Biology degree from a target school (Ivy, sends many to finance) this year and have no experience in finance but am interested in switched from my premed track towards finance. Do you have any suggestions as to how I can proceed along this path? I know BBs are still recruiting for some roles at my school but I doubt that I’ll be competitive with my lack of experience.

    Ultimately, I am interested in working in life science venture capital or starting my own business.

    1. Sorry for the broadness of the statement – I know finance is a large field. I would say I am interested in ER or IB

    2. If you’re graduating this year and have no work experience, you don’t have a chance at traditional finance roles (IB, PE, ER, etc.). Your best bet would be to look for something in corporate finance at a normal company (such as GE’s rotational program) or do something else that’s more closely related, like business development, and then move over from there. A Master’s in Finance would also help with the transition because it would allow you to get internships more easily.

      If none of that works, an MBA would be your Plan C.

  3. I think that VCs are more interested in the field you worked and in your publications than the university you attended. Of course, if you’re from Stanford and the MD is from Stanford, everything is easier…

    1. Sure, but at the undergraduate level, few students will have significant publications. And most candidates recruiting for these roles will have undergraduate experience and some amount of finance experience.

  4. Dr. Chris

    Saying that you need a top 10 uni for the science side to help is kind of nonsense; more accurate is top 100. Being obsessed with top 10 rankings is weird given how much they move around and much the rankings system is easily gamed.

    1. I think the point was simply that you have to attend a relatively good school for the “science” part to work. We can debate what the cut-off line is – maybe it’s top 10, 20, 50, or even 100. But if it’s a school without much of a reputation, even a Ph.D. will help you less than expected.

Leave a Reply

Your email address will not be published. Required fields are marked *